Hesperidin

Updated August 22, 2022

This information is for educational purposes only, to facilitate quality conversations between patients and their personal physician(s). Several additional considerations are required to safely administer any protocol for an individual. This information is NOT intended to diagnose, treat or encourage self-treatment of any medical condition.

Hesperidin is a common flavone glycoside found in citrus fruit such as lemons and sweet oranges. It has several pharmacological activities such as antihyperlipidemic, anti-atherogenic, venotonic, antidiabetic, cardioprotective, anti- antihypertensive, and inflammatory actions. The anti-inflammatory activity of hesperidin was mainly attributed to its antioxidant defense mechanism and suppression of pro-inflammatory cytokine production. Hesperidin exhibited antiviral activity against the influenza virus through a significant reduction of viral replication.

In the below study, Hesperidine was the most affective natural product against SARS-CoV- 2 in Egyptians patients, as it caused inhibition to approximately 100% for infected Vero E6 cell line,

In Vitro–Natural Compounds (Thymol, Carvacrol, Hesperidine, and Thymoquinone) against Sars-Cov2 Strain Isolated from Egypt.2021