Hesperidin is a common flavone glycoside found in citrus fruit such as lemons and sweet oranges. It has several pharmacological activities such as antihyperlipidemic, anti-atherogenic, venotonic, antidiabetic, cardioprotective, anti- antihypertensive, and inflammatory actions. The anti-inflammatory activity of hesperidin was mainly attributed to its antioxidant defense mechanism and suppression of pro-inflammatory cytokine production. Hesperidin exhibited antiviral activity against the influenza virus through a significant reduction of viral replication.

In the below study, Hesperidine was the most affective natural product against SARS-CoV- 2 in Egyptians patients, as it caused inhibition to approximately 100% for infected Vero E6 cell line,

In Vitro–Natural Compounds (Thymol, Carvacrol, Hesperidine, and Thymoquinone) against Sars-Cov2 Strain Isolated from Egypt.2021