Thyroid Research
Updated December 19, 2023
Thyroid Program
IMPORTANT NOTICE
This information is for educational purposes only, to facilitate quality conversations between patients and their personal physician(s). Several essential considerations are required to safely administer any protocol for an individual. This information is NOT intended to diagnose, treat or encourage self-treatment of any medical condition.
Iodine in Thyroid Hormone
- Tyrosine Molar Mass = 181.19,
x2 = 362.38 - Iodine Molar Mass 126.91; x2 = 253.8; x3 = 380.73; x 4= 507.64
- Note that the weight of T4 does NOT equal two tyrosines + 4 iodines since several atoms are removed when the tyrosines combine and when the iodines are attached to the tyrosines
- T4 molar mass is 776.87 grams/mol. C₁₅H₁₃I₄NO₄ Contains four iodine molecules = 507.64 gm; / 776.87 = 65.34% I
-
- 100 mcg T4 has 65.34 mcg of elemental iodine; 16.34 mcg released to make T3
- T3 molar mass is 650.98 grams/mol. Contains 3 iodine molecules = 380.73 gm; / 650.98 = 58.5 % I
- 5 mcg of T3 has ___ mcg of elemental iodine
- T2 molar mass is 525.09 grams/mol. Contains 2 iodine molecules = 253.8 gm; / 525.09 = 48.3% Iodine
- Di-Iodo-Tyrosine Molar Mass = 432.98. Contains 2 iodine molecules = 253.8 gm; / 432.98 = 58.62% Iodine
- Iodo-Tyrosine Molar Mass = 307.09. Contains 1 iodine molecule = 126.9 gm; / 307.09 = 41.32% Iodine
amr_Peripheral Metabolism of Thyroid_2000
Thyroid-disrupting chemicals and brain development–an update
The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases.2017
New insights into thyroid hormone action.2018
Thyroid hormone receptor localization in target tissues
Thyroid-Hormone–Disrupting Chemicals–Evidence for Dose-Dependent Additivity or Synergism
Thyroid-disrupting chemicals and brain development–an update
Thyroid Hormones in Brain Development and Function – Endotext – NCBI Bookshelf
Regulation of T3 Availability in the Developing Brain– The Mouse Genetics Contribution
Thyroglobulin as a biomarker of iodine deficiency– a review.2014
3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines
3,5-Diiodothyronine–A Novel Thyroid Hormone Metabolite and Potent Modulator of Energy Metabolism.r
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