Thyroid-Casein Connection
Updated December 19, 2023
Thyroid Program
IMPORTANT NOTICE
This information is for educational purposes only, to facilitate quality conversations between patients and their personal physician(s). Several essential considerations are required to safely administer any protocol for an individual. This information is NOT intended to diagnose, treat or encourage self-treatment of any medical condition.
Iodine in Thyroid Hormone
- Tyrosine Molar Mass = 181.19,
x2 = 362.38 - Iodine Molar Mass 126.91; x2 = 253.8; x3 = 380.73; x 4= 507.64
- Note that the weight of T4 does NOT equal two tyrosines + 4 iodines since several atoms are removed when the tyrosines combine and when the iodines are attached to the tyrosines
- T4 molar mass is 776.87 grams/mol. C₁₅H₁₃I₄NO₄ Contains four iodine molecules = 507.64 gm; / 776.87 = 65.34% I
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- 100 mcg T4 has 65.34 mcg of elemental iodine; 16.34 mcg released to make T3
- T3 molar mass is 650.98 grams/mol. Contains 3 iodine molecules = 380.73 gm; / 650.98 = 58.5 % I
- 5 mcg of T3 has ___ mcg of elemental iodine
- T2 molar mass is 525.09 grams/mol. Contains 2 iodine molecules = 253.8 gm; / 525.09 = 48.3% Iodine
- Di-Iodo-Tyrosine Molar Mass = 432.98. Contains 2 iodine molecules = 253.8 gm; / 432.98 = 58.62% Iodine
- Iodo-Tyrosine Molar Mass = 307.09. Contains 1 iodine molecule = 126.9 gm; / 307.09 = 41.32% Iodine
This info is also in the iodine section.
While iodine was discovered in the early 1800’s, it was not until the late 1800’s that the structure of thyroid hormone (thyroxine) was clarified. Part of this research involved seeing how iodine attached happily to protein. This discovery was further refined to find that iodine selected the tyrosine amino acids in the proteins that it favored.
Thyroactive Iodinated Proteins.E.P.Reineke.1946
The Formation Of Thyroxine In Iodinated Proteins By E. P. Reineke.1949
Thyroprotein for Increased Milk and Egg Production.1945
preparation of Thyroxine from Casein treated with Iodine.1939
course of progressive iodination of skim milk proteins and casein.1942
The Effect of Thyroprotein on the Growth, Fattening, and Carcass Composition of Swine 1950
