Lithium
Updated November 12, 2024
Elements & Minerals
Lithium for General Brain Protection/Healing
Related Links
Lithium is an essential element which has no RDA and has not made it on the radar screen of nutrition. The growing data on lithium suggests that it is a necessary nutrient in managing stress, including both physiological stress (virus, toxin) and psycho-spiritual stress.  It is essential for autophagy, a process where a cell cleans it’s inner machinery of clutter and debris. Overcrowding of cellular contents is a cusal mechanism of Alzheimers and other degenerative diseases; lithium is essential to prevent and reverse this process via autophagy.
Lithium is excluded from most multi-vitamin and mineral products because of its bad rap. However, it is helpful, and possibly essential, to help defend against and even reverse neurological damage after head trauma and in several neuro-degenerative conditions including dementia.
Most people have only heard of lithium as a drug for psychiatric diseases such as bipolar or manic-depression. However, at these pharmaceutical doses, it damages the thyroid, kidneys and brain. Most patients can not take it for long-term use due to these complications. The dose used in psychiatry is 10-300 times the nutritional dose. It’s equivalent to drinking 20-600 quarts of water per day, rather than 2. That much water is toxic, as is lithium at the doses used.
As you can see in the links below (start from the top articles), lithium is intimately involved in brain health. It not only can protect the brain, it can even help reverse Alzheimers and other neurodegenerative diseases due to its ability to induce autophagy.Â
Overcoming Wrong Perceptions of Lithium
Challenging the Negative Perception of Lithium and Optimizing Its Long-Term Administration.2018Â
A toxicological evaluation of lithium orotate.2021
Lithium Perspectives of nutritional beneficence, dietary intake, biogeochemistry, and biofortification of vegetables and mushrooms.2021.a **  similar and citations
Proper Use of Lithium for Bipolar and Mood
Lithium orotate–A superior option for lithium therapy.2020 **
Medication-free Alternatives for Long-term Maintenance of Bipolar Disorder–A Case Series.2015 **
Lithium trumps valproate for bipolar disorder.2011 **
Lithium orotate in the treatment of alcoholism and related conditions.1986 ** Citated by
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Lithium for Brain Injuries and Inflammation
!!A new avenue for lithium–intervention in traumatic brain injury
! Effects of Lithium on Inflammation.2014.mic
Lithium protects dopaminergic cells from rotenone toxicity via autophagy enhancement
Lithium trumps valproate for bipolar disorder
Effects of lithium and myoinositol
!!Perturbations of Iodine Metabolism by Lithium.nih.1984_p
!!Lithium modifies brain arachidonic and docosahexaenoic metabolism in rat neuroinflammation.mic.2010.nih!
!Citations_ Lithium modifies brain arachidonic and docosahexaenoic metabolism in rat neuroinflammation.mic.2010.nih
The Mood-Stabilizer Lithium Prevents Hippocampal Apoptosis and Improves Spatial Memory in Experimental Meningitis.2014.
Lithium Carbonate vs Orotate Calculations
Lithium Carbonate: Lithium Carbonate has the chemical formula Li2CO3. It is a white, crystalline powder that is highly soluble in water. Lithium carbonate is produced by the reaction of lithium hydroxide and carbon dioxide. The molecular weight of lithium carbonate is 73.89 g/mol. The molecular weight of one lithium (Li) atom is 6.94 g/mol. So, the total weight of two lithium atoms in lithium carbonate is 6.94 * 2 = 13.88 g/mol. The percentage by mass of lithium in lithium carbonate is 13.88/73.89 * 100 = 18.76%.
Lithium Orotate: Lithium Orotate has the chemical formula LiC5H3N2O4. It is a salt that consists of lithium ions (Li+) and orotate ions. Lithium orotate is produced by the reaction of lithium carbonate and orotic acid. The molecular weight of lithium orotate is 168.86 g/mol. The molecular weight of one lithium (Li) atom is 6.94 g/mol. So, the total weight of one lithium atom in lithium orotate is 6.94 g/mol. The percentage by mass of lithium in lithium orotate is 6.94/168.86 * 100 = 4.09%.
Mayo Clinic Prescribing Guidelines!
At this dosage, lithium is toxic
Lithium (Oral Route) Proper Use – Mayo Clinic