Leaky Gut Syndrome is becoming a popular topic in the mainstream.  It has been known about and utilized by holistic practitioners for almost 20 years. While it is helpful to treat leaky gut, the pitfall is that almost everyone these days has a certain degree of “leakiness” due to modern lifestyle. Antibiotics, certain vaccines, pesticides, and other toxins directly and indirectly (by changing gut ecology) cause leakiness. There is no direct or reliable way to measure leaky gut, other than by its clinical features, reviewed in the article (click on image).

References

The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability.2020

Oral Supplementation with Bovine Colostrum Decreases Intestinal Permeability and Stool Concentrations of Zonulin in Athletes.r

Zonulin and Its Regulation of Intestinal Barrier Function–The Biological Door to Inflammation, Autoimmunity, and Cancer.2011

Accuracies of fecal calprotectin, lactoferrin, M2-pyruvate kinase, neopterin and zonulin to predict the response to infliximab in ulcerative colitis – ScienceDirect

Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides ovatus and Are Modifiable by Gut Microbiota Manipulation – ScienceDirect

Gut-dysbiosis-promotes-M2-macrophage-polarization-and-allergic-airway-inflammation-via-fungi-induced-PGE.2013