research
Thyroid Algorithm
Thyroid Program
IMPORTANT NOTICE
This information is for educational purposes only, to facilitate quality conversations between patients and their personal physician(s). Several essential considerations are required to safely administer any protocol for an individual. This information is NOT intended to diagnose, treat or encourage self-treatment of any medical condition.
This page is under development. Working links will provide starting information. Please let us know about your interest in this page by emailing us here, and check back soon.
The basic ideas are:
- TSH is a measure of pituitary function, NOT thyroid function. Therefore TSH is not utilized to assess the body’s (“peripheral”) need for thyroid hormone.
- If only T4 is adjusted, there are only three possible changes, up, or none. If T3 and T4 can be adjusted, there are nine possible changes.
- By measuring just three parameters, Free T4, Free T3 and Reverse T3, each with high, low, or “optimal”, there are 27 possible scenarios.
Proof of Components
rT3 blocks production of T3
!A Study of Extrathyroidal Conversion of T4 to T3.1976.r
Cortisol diverts T4 to rT3 rather than T3
Neuroendocrine System Regulatory Mechanisms–Acute-Coronary-Syndrome.2018
Nonthyroidal Illness Syndrome Across the Ages.2019
TSH measures pituitary, not thyroid function
Coordination-of-hypothalamic-and-pituitary-T3-production-regulates-TSH-expression.2013.r.pdf
Thyroid Hormone is Consumed by Immune Cells During Infection
Which means that the hypothalamus and pituitary (which determine TSH level) may not respond properly during certain types of infections and deficiencies (for more click here).
Articles Supporting the Need/Benefit of T3
Low-T3 Syndrome- A Strong Prognostic Predictor of Death in Patients With Heart Disease.2003
The Swinging Pendulum in Treatment for Hypothyroidism–From (and Toward) Combination Therapy.2019.r
Thyroid Hormone Therapy for Older Adults.2017.nejm
For more information about the benefits and indications for T3, see Combined Thyroid T4-T3 Therapy
File Access
Thyroid Research
Thyroid Program
IMPORTANT NOTICE
This information is for educational purposes only, to facilitate quality conversations between patients and their personal physician(s). Several essential considerations are required to safely administer any protocol for an individual. This information is NOT intended to diagnose, treat or encourage self-treatment of any medical condition.
Iodine in Thyroid Hormone
- Tyrosine Molar Mass = 181.19,
x2 = 362.38 - Iodine Molar Mass 126.91; x2 = 253.8; x3 = 380.73; x 4= 507.64
- Note that the weight of T4 does NOT equal two tyrosines + 4 iodines since several atoms are removed when the tyrosines combine and when the iodines are attached to the tyrosines
- T4 molar mass is 776.87 grams/mol. C₁₅H₁₃I₄NO₄ Contains four iodine molecules = 507.64 gm; / 776.87 = 65.34% I
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- 100 mcg T4 has 65.34 mcg of elemental iodine; 16.34 mcg released to make T3
- T3 molar mass is 650.98 grams/mol. Contains 3 iodine molecules = 380.73 gm; / 650.98 = 58.5 % I
- 5 mcg of T3 has ___ mcg of elemental iodine
- T2 molar mass is 525.09 grams/mol. Contains 2 iodine molecules = 253.8 gm; / 525.09 = 48.3% Iodine
- Di-Iodo-Tyrosine Molar Mass = 432.98. Contains 2 iodine molecules = 253.8 gm; / 432.98 = 58.62% Iodine
- Iodo-Tyrosine Molar Mass = 307.09. Contains 1 iodine molecule = 126.9 gm; / 307.09 = 41.32% Iodine
amr_Peripheral Metabolism of Thyroid_2000
Thyroid-disrupting chemicals and brain development–an update
The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases.2017
New insights into thyroid hormone action.2018
Thyroid hormone receptor localization in target tissues
Thyroid-Hormone–Disrupting Chemicals–Evidence for Dose-Dependent Additivity or Synergism
Thyroid-disrupting chemicals and brain development–an update
Thyroid Hormones in Brain Development and Function – Endotext – NCBI Bookshelf
Regulation of T3 Availability in the Developing Brain– The Mouse Genetics Contribution
Thyroglobulin as a biomarker of iodine deficiency– a review.2014
3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines
3,5-Diiodothyronine–A Novel Thyroid Hormone Metabolite and Potent Modulator of Energy Metabolism.r
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